Anti-SPATA6 / Spermatogenesis-associated protein 6

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. The SPATA6 antibody targets Spermatogenesis-associated protein 6, a membrane-anchored protein encoded by the SPATA6 gene. Spermatogenesis-associated protein 6 plays a crucial role in sperm tail formation, flagellar assembly, and intercellular junction organization during spermatid maturation. It localizes primarily to the manchette and head-tail coupling apparatus, structures that facilitate shaping and attachment of the developing sperm tail. The SPATA6 antibody allows researchers to study sperm morphogenesis, ciliary structure, and reproductive cell differentiation. Spermatogenesis-associated protein 6 contributes to the structural integrity of the connecting piece between the nucleus and flagellum, ensuring proper transmission of motility forces. The SPATA6 antibody supports visualization of this protein during spermiogenesis, revealing dynamic redistribution patterns correlated with microtubule organization. Loss of SPATA6 disrupts flagellar biogenesis and causes male infertility in model organisms, emphasizing its essential role in germ-cell architecture. Beyond testicular expression, Spermatogenesis-associated protein 6 is detected in ciliated epithelial cells, suggesting broader participation in cilium assembly and anchoring. The SPATA6 antibody facilitates these studies and aids in understanding conserved mechanisms that govern axoneme formation and basal-body docking. Its structural role links it to cytoskeletal regulators and motor proteins such as dyneins and kinesins. Mutations in the SPATA6 gene have been associated with asthenozoospermia, characterized by reduced sperm motility. The SPATA6 antibody enables quantification of protein expression in sperm samples and cell lines, providing valuable diagnostic and mechanistic insights. Additionally, SPATA6 participates in the assembly of intercellular junctions during germ-cell development, influencing Sertoli?spermatid adhesion and polarity. The SPATA6 antibody performs effectively in western blotting, immunohistochemistry, and immunofluorescence, typically showing localization to sperm tail and manchette regions. NSJ Bioreagents provides this antibody as a validated, high-specificity reagent for reproductive biology and cell-structure research. By enabling accurate detection of Spermatogenesis-associated protein 6, the SPATA6 antibody supports investigations into flagellar morphogenesis, ciliary function, and molecular mechanisms underlying male infertility.