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The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively. Protein function: Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis. Important for male fertility (PubMed:11870081). [The UniProt Consortium]
Keywords:
Anti-SPACA1, Anti-SAMP32, Anti-Sperm acrosome membrane-associated protein 1, Anti-Sperm acrosomal membrane-associated protein 32, SPACA1 Polyclonal Antibody
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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