Anti-SOX9 / SRY-box transcription factor 9

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. SOX9 antibody detects SRY-box transcription factor 9, a transcriptional regulator that controls chondrogenesis, sex determination, and stem cell maintenance. The UniProt recommended name is SRY-box transcription factor 9 (SOX9). This protein belongs to the SOX (SRY-related HMG-box) family of transcription factors, characterized by a high-mobility group DNA-binding domain that recognizes specific enhancer sequences.Functionally, SOX9 antibody identifies a 509-amino-acid nuclear protein that binds to promoter and enhancer regions of cartilage-specific genes such as COL2A1 and ACAN. SOX9 forms dimers through its HMG domain and recruits transcriptional coactivators to drive cartilage matrix production and skeletal formation. It also plays roles in sex differentiation by activating AMH (anti-M?llerian hormone) transcription during gonadal development.The SOX9 gene is located on chromosome 17q24.3 and is expressed in developing cartilage, gonads, and neural crest-derived tissues. SOX9 is a master regulator of chondrocyte differentiation and is essential for maintaining progenitor cell identity in multiple lineages.Pathologically, mutations or haploinsufficiency of SOX9 cause campomelic dysplasia, a severe skeletal malformation syndrome with sex reversal. Aberrant SOX9 expression also contributes to cancer progression and tissue fibrosis. Research using SOX9 antibody supports studies in developmental biology, transcription regulation, and regenerative medicine.SOX9 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect transcription factors involved in chondrogenesis and lineage specification. NSJ Bioreagents provides SOX9 antibody reagents optimized for studies in cartilage biology, stem cell differentiation, and developmental genetics.Structurally, SRY-box transcription factor 9 contains an HMG DNA-binding domain and transactivation regions that mediate chromatin remodeling and transcriptional activation. This antibody supports detailed analysis of SOX9's regulatory mechanisms in development and disease.