Protein function: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. [The UniProt Consortium]
Human (Expected: X. Laevis, X. Tropicalis, Chicken, Sheep)
synthetic peptide. The epitope recognized by A301-741A-T maps to a region between residue 295 and 317 of human SRY (sex determining region Y)-box 2 using the numbering given in entry NP_003097.1 (GeneID 6657).