Anti-SOX10 / Transcription factor SOX10, clone rSOX10/991

1 mg/ml in 1X PBS, BSA free, sodium azide free. Transcription factor SOX10 Antibody recognizes SRY-box transcription factor 10, encoded by the SOX10 gene and belonging to the SOX family of high mobility group box DNA-binding proteins. SOX10 is a nuclear transcription factor characterized by a conserved HMG-box domain that enables sequence-specific DNA binding and modulation of gene expression programs essential for neural crest development. Transcription factor SOX10 Antibody detects this predominantly nuclear protein that regulates lineage specification and differentiation of neural crest-derived cell populations.During embryogenesis, SOX10 plays a central role in neural crest cell survival, migration, and differentiation. It is required for development of melanocytes, Schwann cells, peripheral glia, and components of the enteric nervous system. In melanocyte biology, SOX10 functions upstream of MITF and regulates genes involved in pigment synthesis, melanocyte proliferation, and cellular maintenance. In peripheral nerve development, SOX10 coordinates Schwann cell maturation and myelination programs through interaction with signaling pathways such as Wnt, Notch, and neuregulin-mediated cascades.In adult tissues, SOX10 expression remains largely restricted to melanocytes located within the basal layer of the epidermis and hair follicles and to Schwann cells associated with peripheral nerves. This lineage-specific distribution makes SOX10 antibody a valuable marker for identifying neural crest-derived cell types. The characteristic nuclear staining pattern reflects the transcriptional function of SOX10 within positive cells.SOX10 has significant relevance in cancer research. Expression is frequently observed in melanoma, malignant peripheral nerve sheath tumors, and clear cell sarcoma, where nuclear localization supports identification of melanocytic or neural crest differentiation. SOX10 expression has also been reported in subsets of basal-like breast carcinoma and salivary gland neoplasms, reflecting shared developmental regulatory pathways. Altered SOX10 signaling has been associated with tumor progression and cellular plasticity in melanoma and related malignancies.Transcription factor SOX10 Antibody / SOX10 (clone rSOX10/991) is a recombinant monoclonal antibody suitable for detecting SOX10 protein expression in research applications focused on neural crest biology, melanocyte differentiation, peripheral nerve studies, and tumor characterization.