Anti-SOX10 / SRY-box transcription factor 10, clone rSOX10/13506

0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide. SRY-box transcription factor 10 Antibody recognizes SOX10, a nuclear DNA-binding protein encoded by the SOX10 gene and belonging to the SOX family of high mobility group box transcription factors. SOX10 contains a conserved HMG-box domain that enables sequence-specific DNA binding and transcriptional activation of genes essential for neural crest development and lineage specification. This transcription factor localizes predominantly to the nucleus, consistent with its regulatory role in gene expression programs controlling cell fate determination.SOX10 plays a critical role during embryogenesis, where it regulates neural crest cell survival, migration, and differentiation. It is indispensable for formation of melanocytes, Schwann cells, peripheral glial cells, and elements of the enteric nervous system. In melanocyte biology, SOX10 functions upstream of MITF and influences pigmentation pathways by regulating genes involved in melanin synthesis and melanocyte maintenance. In peripheral nerve development, SOX10 contributes to Schwann cell maturation and myelination through interaction with signaling pathways including Wnt, Notch, and neuregulin-mediated mechanisms.In adult tissues, SOX10 expression is largely restricted to melanocytes within the basal epidermis and hair follicles and to Schwann cells associated with peripheral nerves. This lineage-restricted distribution makes SOX10 antibody a valuable marker for identifying neural crest-derived cell populations. Nuclear staining is characteristic of SOX10 detection and reflects its function as a transcription factor.SOX10 has significant relevance in oncology research. Expression is frequently observed in melanoma, malignant peripheral nerve sheath tumors, and clear cell sarcoma, where nuclear staining supports identification of melanocytic or neural crest differentiation. SOX10 expression has also been reported in subsets of triple-negative breast carcinoma and salivary gland tumors exhibiting basal-like or myoepithelial characteristics. Dysregulated SOX10 activity may contribute to tumor progression and cellular plasticity in melanoma and related malignancies.SRY-box transcription factor 10 Antibody / SOX10 (clone rSOX10/13506) is a recombinant monoclonal antibody suitable for detecting SOX10 protein expression in research applications focused on neural crest biology, melanocyte differentiation, peripheral nerve studies, and tumor characterization.