Anti-SOS1 / Son of sevenless 1, clone ABBE-19

Rabbit IgG in stabilizing components, phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Son of Sevenless 1 (SOS1) is a cytoplasmic signaling protein encoded by the human SOS1 gene and functions as a Ras guanine nucleotide exchange factor that activates Ras proteins during growth factor receptor signaling. Son of Sevenless 1 Antibody / SOS1 (clone ABBE-19) targets this critical Ras pathway regulator that mediates GDP-GTP exchange on Ras proteins, enabling downstream signaling through the MAPK and ERK pathways. SOS1 belongs to the Son of Sevenless family of Ras activators and is widely expressed in many tissues where it participates in receptor tyrosine kinase signaling and cellular proliferation pathways.SOS1 antibody, also referred to as Son of Sevenless homolog 1 antibody in the literature, recognizes a signaling protein that serves as a central mediator linking activated receptor complexes to Ras activation. SOS1 interacts with adaptor proteins such as GRB2 following activation of receptors including EGFR and other receptor tyrosine kinases. This interaction recruits SOS1 to the plasma membrane where it promotes the exchange of GDP for GTP on Ras, converting Ras into its active signaling state. Through this mechanism, SOS1 plays an essential role in transmitting extracellular growth signals to intracellular kinase cascades.The SOS1 protein contains multiple functional domains that regulate Ras activation and membrane recruitment. These include a Dbl homology domain and pleckstrin homology domain involved in membrane association, a Ras exchanger motif responsible for catalytic nucleotide exchange, and proline-rich regions that mediate binding to SH3 domain-containing adaptor proteins. Structural studies have demonstrated that SOS1 adopts an autoinhibited conformation that becomes activated upon membrane recruitment and interaction with Ras-GTP, creating a positive feedback mechanism that amplifies Ras signaling.SOS1 functions within the Ras-MAPK signaling pathway, a fundamental regulatory system controlling cell growth, differentiation, and survival. Dysregulation of Ras signaling can lead to abnormal cellular proliferation and is strongly associated with oncogenic transformation. Alterations in SOS1 activity have been implicated in developmental disorders such as Noonan syndrome as well as in multiple cancer types where Ras signaling pathways are aberrantly activated.In addition to its role in growth factor signaling, SOS1 contributes to broader cellular signaling networks that regulate cytoskeletal organization and cell migration. The protein can interact with multiple adaptor proteins and signaling complexes, allowing it to integrate signals from different receptor pathways. These interactions position SOS1 as an important hub in cellular signaling networks controlling proliferation and differentiation.A recombinant rabbit monoclonal clone ABBE-19 antibody targets SOS1 and can be used to investigate Ras pathway signaling, receptor tyrosine kinase activation, and downstream MAPK signaling mechanisms. Detection of SOS1 expression is valuable for studying signaling networks involved in cell growth, oncogenic transformation, and developmental signaling pathways.