Anti-SNX27 / Sorting nexin-27

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. SNX27 antibody detects Sorting nexin-27, encoded by the SNX27 gene on chromosome 1q21.1. SNX27 antibody is widely used in studies of endosomal trafficking, receptor recycling, and neurological disorders. Sorting nexins are a diverse family of endosomal proteins characterized by PX domains that bind phosphoinositides. SNX27 is unique among sorting nexins in containing a PDZ domain, which recognizes PDZ-binding motifs in target proteins, and an FERM-like domain, which regulates interactions with cytoskeletal and signaling proteins. This structural versatility enables SNX27 to link endosomal sorting with cell signaling and polarity.Structurally, SNX27 is a ~61 kDa protein containing three functional domains: an N-terminal PDZ domain, a central PX domain, and a C-terminal FERM-like domain. The PX domain mediates binding to phosphatidylinositol-3-phosphate in endosomal membranes, targeting SNX27 to recycling endosomes. The PDZ domain recognizes a wide variety of membrane proteins with C-terminal PDZ-binding motifs, including receptors, transporters, and channels.Functionally, SNX27 promotes endosome-to-plasma membrane recycling of nutrient transporters, GPCRs, and signaling receptors. This ensures surface availability of proteins like glucose transporters (GLUT1), beta-adrenergic receptors, and NMDA receptors, which are essential for metabolism, neurotransmission, and signaling. SNX27 works within the retromer complex to mediate cargo selection and retrieval. Loss of SNX27 impairs receptor recycling, leading to reduced nutrient uptake and signaling defects. Researchers employ SNX27 antibody to study receptor trafficking, endosome biology, and neurological disease mechanisms.Clinically, SNX27 dysfunction is associated with Down syndrome, neurodevelopmental delay, and epilepsy. Reduced SNX27 expression contributes to synaptic dysfunction and impaired glutamate receptor recycling in Down syndrome models. Its broad role in trafficking links it to metabolic disease, immunity, and cancer, where altered receptor localization influences signaling outcomes. NSJ Bioreagents provides SNX27 antibody to support neuroscience, immunology, and cell biology research.Experimentally, SNX27 antibody is applied in western blotting to detect the ~61 kDa protein, in immunofluorescence microscopy to study endosomal distribution, and in immunohistochemistry to examine tissue-specific patterns. Co-immunoprecipitation with SNX27 antibody identifies PDZ-binding cargo proteins and retromer complex partners.