Anti-SNX27

Polyclonal Antibody against Human SNX27, Gene description: sorting nexin 27, Alternative Gene Names: KIAA0488, MGC20471, MY014, Validated applications: ICC, Uniprot ID: Q96L92, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C. Protein function: Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C- terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes. [The UniProt Consortium] Mouse gene identity: 99% Rat gene identity: 99%