Anti-SNX1 (IHC)

Anti-SNX1 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00433-T 10 µl (5+ slides) -

6 - 10 business days*

131.00€
IHC-00433 100 µl (50+ slides) -

6 - 10 business days*

493.00€
 
Protein function: Involved in several stages of intracellular trafficking. Interacts with... more
Product information "Anti-SNX1 (IHC)"
Protein function: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle- to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17550970, PubMed:17101778, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer- independent membrane remodeling such as lamellipodium formation, the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498). [The UniProt Consortium]
Keywords: Anti-SNX1, Anti-Sorting nexin-1
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00433

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Rat, Zebrafish, X. Laevis, X. Tropicalis, Chicken, Turkey, Bovine, Dog, Horse, Rabbit, Guinea Pig, Swine, Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, West Indian Ocean Coelacanth, Spotted Green Pufferfish)
Immunogen: synthetic peptide. The epitope recognized by IHC-00433 maps to a region between residue 475 and the C-terminus (residue 422) of human Sorting Nexin 1 using the numbering given in entry NP_003090.2 (GeneID 6642).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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