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Protein function: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. [The UniProt Consortium]
Keywords:
Anti-SMYD2, Anti-KMT3C, Anti-HSKM-B, EC=2.1.1.-, EC=2.1.1.43, Anti-Lysine N-methyltransferase 3C, Anti-Histone methyltransferase SMYD2, Anti-N-lysine methyltransferase SMYD2, Anti-SET and MYND domain-containing protein 2, SMYD2 Polyclonal Antibody
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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