Anti-SMC6

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA042733.25	25 µl		-		7 - 10 business days*		335.00€
ATA-HPA042733.100	100 µl		-		7 - 10 business days*		446.00€

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Protein function: Core component of the SMC5-SMC6 complex, a complex involved in DNA... more

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Product information "Anti-SMC6"

Protein function: Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 81% and to rat: 84%

Keywords:	Anti-SMC6, Anti-hSMC6, Anti-SMC-6, Anti-SMC6L1, Anti-SMC protein 6, Anti-Structural maintenance of chromosomes protein 6
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA042733

Properties

Application:	IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: KEEHGKIKRE ELDVKHALSY NQRQLKELKD SKTDRLKRFG PNVPALLEAI DDAYRQGHFT YKPVGPLGAC IHLRDPELAL AIESCL (ATA-APrEST79170)