Anti-SMC1B / Structural maintenance of chromosomes protein 1B

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. SMC1B antibody detects Structural maintenance of chromosomes protein 1B, a cohesin complex component essential for chromosome cohesion during meiosis. Encoded by the SMC1B gene on chromosome 22q13.33, this protein is a meiosis-specific paralog of the somatic cohesin subunit SMC1A. SMC1B forms part of the cohesin ring complex that links sister chromatids and facilitates homologous recombination and synapsis. It ensures accurate chromosome segregation and genomic integrity in germ cells, playing a critical role in gametogenesis and fertility.SMC1B forms heterodimers with SMC3 and associates with meiosis-specific cohesin components such as REC8, STAG3, and RAD21L. Together, these proteins establish and maintain cohesion between homologous chromosomes from prophase I until anaphase I, preventing premature separation. SMC1B also contributes to chromatin organization, double-strand break repair, and gene regulation during meiosis. Its expression is restricted mainly to germ cells in the testes and ovaries, though low levels may be detected in certain somatic tissues under specific developmental conditions.The SMC1B antibody is used in cell biology, reproductive, and chromatin research to investigate cohesin complex formation and meiotic chromosome dynamics. Western blot analysis identifies a 145 kilodalton band corresponding to SMC1B, while immunofluorescence reveals chromosomal axis localization in meiotic cells. This antibody supports studies of meiotic cohesion, synaptonemal complex assembly, and chromosomal recombination.Deficiency or mutation of SMC1B disrupts chromosome pairing and leads to infertility, meiotic arrest, or aneuploidy. Beyond meiosis, SMC1B may contribute to chromatin architecture and DNA repair in somatic cells. The SMC1B antibody provides a powerful tool for characterizing cohesin-mediated chromosome interactions and meiotic mechanisms. NSJ Bioreagents supplies this antibody validated for western blotting and immunofluorescence, ensuring reliable performance in chromosomal cohesion and germ cell research.