Anti-SMAD7

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA028897.25	25 µl		-		7 - 10 business days*		330.00€
ATA-HPA028897.100	100 µl		-		7 - 10 business days*		463.00€

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Protein function: Antagonist of signaling by TGF-beta (transforming growth factor) type 1... more

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Product information "Anti-SMAD7"

Protein function: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members, has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 99% and to rat: 99%

Keywords:	Anti-SMAD7, Anti-MADH7, Anti-Smad7, Anti-hSMAD7, Anti-SMAD 7, Anti-MAD homolog 8, Anti-MAD homolog 7, Anti-SMAD family member 7, Anti-Mothers against DPP homolog 8, Anti-Mothers against DPP homolog 7, Anti-Mothers against decapentaplegic homolog 7
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA028897

Properties

Application:	IHC, ICC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: EVKRLCCCES YGKINPELVC CNPHHLSRLC ELESPPPPYS RYPMDFLKPT ADCPDAVPSS AETGGTNYLA PGGLSDSQLL LEPGDRSHWC VVAYWEEKTR VGRLYCVQEP SLDIFYDLPQ GNG (ATA-APrEST86713)