Anti-Smad7

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG20572.50	50 µl		-	-	6 - 14 business days*		551.00€

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Protein function: Antagonist of signaling by TGF-beta (transforming growth factor) type 1... more

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Product information "Anti-Smad7"

Protein function: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members, has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. [The UniProt Consortium]

Keywords:	Anti-SMAD7, Anti-Smad7, Anti-MADH7, Anti-SMAD 7, Anti-hSMAD7, Anti-MAD homolog 7, Anti-MAD homolog 8, Anti-SMAD family member 7, Anti-Mothers against DPP homolog 8, Anti-Mothers against DPP homolog 7, Anti-Mothers against decapentaplegic homolog 8
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG20572

Properties

Application:	WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: mouse, rat)
Immunogen:	Synthetic peptides around aa. 12-29 (RLWRSRAPGGEDEEEGAG) and aa. 36-50 (ELRGEGATDSRAHGA) of Human SMAD7. This sequence is 100% or highly conserved between Human and multiple species
MW:	53 kD
Format:	Purified