Anti-SLIRP / SRA stem-loop interacting RNA-binding protein

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. SLIRP antibody detects SRA stem-loop interacting RNA-binding protein, a mitochondrial RNA-binding protein that modulates gene expression, oxidative phosphorylation, and steroid receptor signaling. SLIRP stabilizes mitochondrial mRNAs and participates in post-transcriptional regulation of respiratory chain components. The SLIRP antibody is widely used in mitochondrial biology and molecular endocrinology to study RNA regulation, energy metabolism, and hormone receptor activity.SLIRP is encoded by the SLIRP gene located on human chromosome 14q13.3. The protein is approximately 111 amino acids long and contains an RNA recognition motif responsible for binding SRA (steroid receptor RNA activator) and mitochondrial transcripts. SLIRP localizes primarily to the mitochondrial matrix but also associates with nuclear hormone receptors, linking energy metabolism with transcriptional regulation.The SLIRP antibody detects a 12 kilodalton band by western blot and exhibits mitochondrial and nuclear staining under immunofluorescence. SLIRP forms complexes with LRPPRC, ensuring stabilization and translation of mitochondrial mRNAs encoding respiratory complex subunits. Loss of SLIRP leads to reduced mitochondrial translation, impaired oxidative phosphorylation, and decreased ATP production.Beyond mitochondrial function, SLIRP interacts with steroid receptors such as estrogen receptor alpha and glucocorticoid receptor, modulating their transcriptional activity. By coupling nuclear hormone signaling with mitochondrial bioenergetics, SLIRP coordinates cellular responses to hormonal and metabolic cues. Dysregulation of SLIRP expression contributes to metabolic disorders, neurodegeneration, and certain cancers where mitochondrial dysfunction plays a role.Because SLIRP integrates transcriptional control and mitochondrial energy metabolism, it represents a valuable target for understanding gene expression coordination and metabolic adaptation. NSJ Bioreagents provides a validated SLIRP antibody optimized for western blot, immunofluorescence, and mitochondrial studies, supporting investigations into RNA processing, hormone receptor function, and oxidative metabolism.