Anti-SLFN12 / Schlafen family member 12

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. SLFN12 antibody detects Schlafen family member 12, a cytoplasmic regulatory protein involved in epithelial differentiation, translational control, and antiviral defense. Encoded by the SLFN12 gene on chromosome 17q12, this member of the Schlafen family functions as a modulator of protein synthesis and cellular differentiation through interactions with the ribosome and mRNA translation machinery. SLFN12 expression is induced by interferon signaling and during epithelial maturation, linking immune regulation with cell differentiation.Structurally, SLFN12 is a 578-amino-acid protein of approximately 66 kilodaltons containing an N-terminal Schlafen domain and C-terminal helicase-like motifs that mediate RNA and ribosome binding. Unlike some other Schlafen family members, SLFN12 lacks DNA helicase activity but regulates translation elongation and protein turnover through non-catalytic interactions. It localizes mainly to the cytoplasm and perinuclear region, where it acts as a translational repressor for specific mRNAs involved in proliferation and stress response.The SLFN12 antibody is widely used in immunology, virology, and epithelial biology research to study interferon-stimulated gene expression, translational regulation, and mucosal differentiation. Western blot analysis identifies a 66 kilodalton band corresponding to SLFN12, while immunofluorescence shows cytoplasmic and perinuclear staining in epithelial and immune cells. This antibody supports studies examining the intersection of innate immune signaling, protein translation, and epithelial homeostasis.Functionally, SLFN12 inhibits translation of certain viral and cellular mRNAs, contributing to the antiviral defense mechanisms of interferon-stimulated cells. It also regulates epithelial differentiation in intestinal and airway epithelia by repressing translation of growth-promoting proteins and promoting barrier maturation. Dysregulation of SLFN12 expression is linked to abnormal epithelial remodeling, inflammation, and tumorigenesis. The SLFN12 antibody provides a high-quality tool for exploring Schlafen protein function, immune signaling, and translational control mechanisms. NSJ Bioreagents validates this antibody for its applications, ensuring consistent performance for studies of immune and epithelial biology.