Anti-SLC9A8 / Sodium/hydrogen exchanger 8 / NHE8

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. SLC9A8 antibody detects Sodium/hydrogen exchanger 8, a membrane transporter involved in intracellular pH regulation and sodium ion homeostasis. The UniProt recommended name is Sodium/hydrogen exchanger 8 (SLC9A8). Also known as NHE8, this transporter belongs to the solute carrier family 9 and mediates electroneutral exchange of sodium and hydrogen ions across cellular membranes.Functionally, SLC9A8 antibody identifies a 576-amino-acid integral membrane protein localized primarily to the trans-Golgi network and apical plasma membrane. SLC9A8 contributes to luminal pH control in endosomes and the Golgi apparatus, influencing protein sorting and vesicular trafficking. It also maintains intestinal epithelial ion balance and supports mucosal barrier function.The SLC9A8 gene is located on chromosome 20q13.13 and is widely expressed, with highest levels in kidney, intestine, and testis. NHE8 activity complements other sodium/hydrogen exchangers such as NHE3, particularly during development and epithelial differentiation. Its regulation ensures proper acid-base balance and cellular volume control.Pathologically, loss of SLC9A8 function has been associated with intestinal dysfunction, renal tubular acidosis, and retinal degeneration. In epithelial cells, SLC9A8 deficiency impairs vesicular acidification and protein trafficking. Research using SLC9A8 antibody aids studies in membrane transport, epithelial physiology, and cellular pH regulation.SLC9A8 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect sodium/hydrogen exchangers and intracellular transport proteins. NSJ Bioreagents provides SLC9A8 antibody reagents optimized for studies of ion transport, cellular homeostasis, and membrane biology.Structurally, Sodium/hydrogen exchanger 8 contains multiple transmembrane helices forming an ion translocation pathway and a cytoplasmic regulatory domain modulated by intracellular pH and signaling kinases. This antibody supports investigation of SLC9A8's function in vesicular trafficking and epithelial ion regulation.