Anti-SLC7A14 / Solute carrier family 7 member 14

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. SLC7A14 antibody detects Solute carrier family 7 member 14, a lysosomal cationic amino acid transporter critical for maintaining lysosomal homeostasis and neuronal survival. The UniProt recommended name is Solute carrier family 7 member 14 (SLC7A14), with alternate names cationic amino acid transporter-related protein 1 (CATR1), SLC7A14 protein, and lysosomal arginine transporter. SLC7A14 belongs to the solute carrier (SLC) superfamily of amino acid transporters, specifically the cationic amino acid transporter-like (CAT-like) subgroup.Functionally, SLC7A14 antibody recognizes a multi-pass transmembrane protein localized to the lysosomal membrane, where it facilitates the uptake of arginine and other cationic amino acids from the cytoplasm into the lysosome. This transport is essential for maintaining amino acid balance, lysosomal integrity, and mTOR signaling. SLC7A14 is highly expressed in sensory neurons of the retina and cochlea, and loss of function leads to progressive vision and hearing loss. Mutations in SLC7A14 cause autosomal recessive retinitis pigmentosa and auditory neuropathy, making it a gene of growing clinical significance in neurodegeneration research.At the molecular level, SLC7A14 contains 14 predicted transmembrane helices and shares structural features with other CAT family members but displays lysosome-specific trafficking signals. The transporter's localization depends on interactions with adaptor protein complexes such as AP-3 and lysosomal membrane proteins including LAMP1. SLC7A14 antibody is employed to study neuronal lysosome biology, amino acid metabolism, and neurodegenerative disease models. Studies demonstrate that reduced SLC7A14 impairs lysosomal function, increases oxidative stress, and triggers neuronal apoptosis. Expression analysis shows enrichment in inner hair cells, photoreceptors, and hippocampal neurons, linking it to sensory function and neural plasticity.The SLC7A14 gene is located on chromosome 3q26.2 and encodes a 561-amino acid protein. Beyond sensory tissues, SLC7A14 transcripts have been detected in endocrine cells and fibroblasts, suggesting roles in nutrient sensing and metabolic regulation. Overexpression experiments indicate SLC7A14 contributes to amino acid-regulated mTORC1 activation, coupling lysosomal nutrient availability with cellular growth signals. The SLC7A14 antibody is valuable for immunofluorescence and confocal microscopy to confirm lysosomal localization and evaluate expression changes in disease models. NSJ Bioreagents provides well-characterized antibodies validated for human, mouse, and rat samples, supporting research into lysosomal transport and neurodegenerative mechanisms.