Anti-SLC3A2/CD98 Heavy Chain Rabbit Monoclonal Antibody (Clone 048)

Solute carrier family 3 member 2 (SLC3A2), also known as CD98 heavy chain (CD98hc), is a type II transmembrane glycoprotein. It is expressed in all cell types except platelets, with the highest levels in the gastrointestinal tract and renal tubules. SLC3A2 is composed of an extracellular domain, a single-pass transmembrane region, and a cytoplasmic domain. It heterodimerizes with various light chains, including the large neutral amino acids transporter small subunit 1 (LAT1) and LAT2, to form sodium-dependent transporters for neutral and positively charged amino acids and associates with beta integrins to regulate integrin affinity and signaling, resulting in alterations in cell proliferation, adhesion, migration, and differentiation. SLC3A2 is associated with tumor growth, aggressiveness, and poor prognosis in patients with biliary tract cancer. It is also expressed on low-density neutrophils (LDNs), a subset of the neutrophil population that expands in patients with autoimmune disease, and is positively correlated with disease severity in patients with systemic lupus erythematosus (SLE). Cayman's SLC3A2/CD98 Heavy Chain Rabbit Monoclonal Antibody (Clone 048) can be used for immunohistochemistry (IHC) (paraffin).Synonyms: CD98, CD98hc, 4F2HC, Solute Carrier Family 3 Member 2. Immunogen: Recombinant mouse SLC3A2. Clone Designation: 048. Formulation: (Request formulation change), 50 or 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: 0.2 µm filtered solution in PBS. Host: Rabbit. Isotype: IgG. Applications: IHC-P.