Anti-SLC14A1 / Urea transporter 1 / UT-B

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. The SLC14A1 antibody targets Urea transporter 1 (UT-B), a membrane channel encoded by the SLC14A1 gene. Urea transporter 1 facilitates rapid, passive transport of urea across cell membranes, maintaining osmotic balance in tissues such as the kidney, red blood cells, and bladder. As a member of the solute carrier family, Urea transporter 1 is integral to urinary concentrating mechanisms and nitrogen metabolism. The SLC14A1 antibody provides a valuable reagent for studying renal physiology, erythrocyte transport, and metabolic homeostasis.Urea transporter 1 is highly expressed in erythrocytes, renal descending vasa recta, and bladder epithelium, where it regulates urea permeability and water reabsorption. The protein forms a transmembrane channel composed of multiple membrane-spanning helices that enable facilitated urea diffusion without energy expenditure. The SLC14A1 antibody allows visualization of this transporter in tissue sections and cell membranes, offering insight into how urea flux contributes to osmoregulation and urinary concentration.Genetic polymorphisms in SLC14A1 have been linked to differences in erythrocyte antigen systems (the Kidd blood group, JK), as well as altered susceptibility to hemolysis and bladder cancer. The SLC14A1 antibody aids in detecting protein variants and assessing their expression patterns. In the kidney, Urea transporter 1 cooperates with aquaporins to control medullary osmolarity, optimizing urine concentration during water deprivation. Studies using this antibody have clarified how transporter regulation by hormones such as vasopressin adjusts urea recycling to maintain fluid balance.Beyond its renal role, Urea transporter 1 participates in nitrogen balance and tissue detoxification. In erythrocytes, it ensures rapid equilibration of plasma and cytosolic urea concentrations, preventing osmotic stress. The SLC14A1 antibody is a key reagent for investigating how transporter dysfunction affects blood cell stability, renal concentrating ability, and urinary tract physiology. It also helps characterize SLC14A1 expression changes associated with metabolic disorders, dehydration, and cancer.NSJ Bioreagents provides the SLC14A1 antibody as a validated reagent for western blotting, immunofluorescence, and immunohistochemistry. It yields clear membrane localization consistent with transporter expression. By enabling detailed study of Urea transporter 1, this antibody supports research into kidney function, erythrocyte physiology, and solute transport mechanisms critical for maintaining systemic osmotic equilibrium.