Anti-SLC11A2 / Solute carrier family 11 member 2

In 1X PBS, pH 7.4, with 0.09% sodium azide. SLC11A2, also known as Solute carrier family 11 member 2 and Divalent metal ion transporter 1 (DMT1), SLC11A2 is responsible for transporting essential metal ions, such as iron and manganese, across cell membranes. These metal ions are vital for various biological processes, including oxygen transport, energy production, and DNA synthesis. Research has shown that mutations in the SLC11A2 gene can lead to various health conditions, such as iron-deficiency anemia and neurodegenerative disorders. Protein function: Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1 (PubMed:17109629, PubMed:17293870, PubMed:22736759, PubMed:25326704, PubMed:25491917). Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+) (PubMed:17109629, PubMed:17293870, PubMed:22736759, PubMed:25326704, PubMed:25491917). Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells. Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense (PubMed:24448823). Can mediate uncoupled fluxes of either protons or metal ions. [The UniProt Consortium]