Anti-SIGIRR / Single Ig IL-1-related receptor

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. The SIGIRR antibody targets Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain-containing protein, a negative regulator of interleukin and toll-like receptor signaling encoded by the SIGIRR gene. Also known as Toll/IL-1 receptor 8 (TIR8), this protein modulates inflammatory responses by inhibiting MyD88- and IRAK-mediated signal transduction. Single immunoglobulin and toll-interleukin 1 receptor domain-containing protein acts as a brake on excessive innate immune activation, helping to maintain immune tolerance and prevent tissue damage. The SIGIRR antibody provides researchers with a crucial reagent to study innate immune regulation and inflammation control mechanisms.Single immunoglobulin and toll-interleukin 1 receptor domain-containing protein is a type I transmembrane glycoprotein with a single extracellular immunoglobulin-like domain, a transmembrane segment, and an intracellular TIR domain. Unlike classical toll-like receptors, its cytoplasmic TIR domain lacks certain signaling motifs, rendering it inhibitory. The SIGIRR antibody enables detection of this regulatory receptor in epithelial, endothelial, and immune cells, allowing studies on how it fine-tunes inflammatory signaling.Functionally, SIGIRR interacts with IL-1 receptor and TLR complexes to disrupt adaptor recruitment and downstream kinase activation. It thereby attenuates NF-?B and MAPK pathway activation in response to cytokine or pathogen-associated stimuli. The SIGIRR antibody supports investigations into these signaling mechanisms and helps define how reduced SIGIRR expression contributes to hyperinflammatory states and autoimmune diseases. Mice deficient in this protein exhibit enhanced inflammatory responses and are more susceptible to colitis and sepsis, underscoring its protective role.Beyond inflammation, Single immunoglobulin and toll-interleukin 1 receptor domain-containing protein contributes to mucosal homeostasis, microbiota balance, and epithelial integrity. In the gut and lungs, it limits IL-1-driven inflammation and maintains tolerance to commensal organisms. The SIGIRR antibody is used in immunohistochemistry and flow cytometry to evaluate tissue distribution, revealing strong expression on epithelial cells of mucosal surfaces. Aberrant regulation of SIGIRR has been linked to inflammatory bowel disease, asthma, and cancer, where loss of this inhibitory signaling may favor tumor-promoting inflammation.The SIGIRR antibody performs effectively in western blotting, immunofluorescence, and immunohistochemistry. It provides clear membrane and cytoplasmic staining consistent with receptor localization. NSJ Bioreagents supplies this antibody with high specificity and reproducibility, supporting research in immunology, mucosal biology, and inflammation resolution. By enabling detailed analysis of Single immunoglobulin and toll-interleukin 1 receptor domain-containing protein, the SIGIRR antibody contributes to understanding immune balance, tolerance mechanisms, and inflammatory disease pathogenesis.