Anti-SIAE/sialate O-acetylesterase Monoclonal Antibody

This gene encodes an enzyme which removes 9-O-acetylation modifications from sialic acids. Mutations in this gene are associated with susceptibility to autoimmune disease 3. Multiple transcript variants encoding different isoforms, found either in the cytosol or in the lysosome, have been found for this gene. Protein function: Catalyzes the removal of O-acetyl ester groups from position 9 of the free diacetylated sialate N-acetyl-9-O-acetylneuraminate (Neu5,9Ac2) in the cytosol and of the diacetylated sialate residues of sialylglycoconjugates in the lysosomes (Probable). Together with the sialate-O-acetyltransferase they regulate the balance of acetylated sialoglycoconjugates, key players in various processes such as cell- cell interactions, host-pathogen recognition, and tumor antigenicity (PubMed:21803834). [The UniProt Consortium]