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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ARG63092.100 | 100 µg | - | - |
6 - 14 business days* |
624.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the... more
Product information "Anti-SHIP-1, clone SHIP-01"
Protein function: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. [The UniProt Consortium]
Keywords: | Anti-SHIP, Anti-hp51CN, Anti-INPP5D, Anti-SHIP-1, Anti-SIP-145, Anti-p150Ship, EC=3.1.3.86, Anti-SH2 domain-containing inositol phosphatase 1, Anti-SH2 domain-containing inositol 5'-phosphatase 1, Anti-Inositol polyphosphate-5-phosphatase of 145 kDa |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG63092 |
Properties
Application: | FC, WB |
Antibody Type: | Monoclonal |
Clone: | SHIP-01 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Peptide coresponding to a sequence within N-terminal domain of Human SHIP-1 |
Format: | Liquid |
Database Information
KEGG ID : | K03084 | Matching products |
UniProt ID : | Q92835 | Matching products |
Gene ID | GeneID 3635 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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