Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-019A-T 10 µl (10 µg) -

3 - 9 business days*

A302-019A 100 µl (100 µg) -

3 - 9 business days*

Protein function: Signaling adapter that couples activated growth factor receptors to signaling... more
Product information "Anti-Shc1"
Protein function: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. [The UniProt Consortium]
Keywords: Anti-SHC, Anti-SHC1, Anti-SH2 domain protein C1, Anti-SHC-transforming protein 3, Anti-SHC-transforming protein A, Anti-SHC-transforming protein 1, Anti-Src homology 2 domain-containing-transforming protein C1
Supplier: Bethyl Laboratories
Supplier-Nr: A302-019A


Application: IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Mouse, Rat, Orangutan)
Immunogen: synthetic peptide. The epitope recognized by A302-019A-T maps to a region between residue 300 and 350 of human SHC (Src homology 2 domain containing) transforming protein 1 using the numbering given in entry NP_892113.4 (GeneID 6464).
Format: Antigen Affinity Purified

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Shipping: +4°C (International: +4°C)
Our products are for laboratory research use only: Not for administration to humans!
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