Anti-SHANK3, clone S69

Anti-SHANK3, clone S69
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG24125.50 50 µg - -

6 - 14 business days*

536.00€
 
Protein function: Major scaffold postsynaptic density protein which interacts with multiple... more
Product information "Anti-SHANK3, clone S69"
Protein function: Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. [The UniProt Consortium]
Keywords: Anti-Shank3, Anti-ProSAP2, Anti-Prosap2, Anti-SPANK-2, Anti-Proline-rich synapse-associated protein 2, Anti-SH3 and multiple ankyrin repeat domains protein 3
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG24125

Properties

Application: ICC, IF, IHC (paraffin), IP, WB
Antibody Type: Monoclonal
Clone: S69
Conjugate: No
Host: Mouse
Species reactivity: human, mouse, rat
Immunogen: Synthetic peptide of Rat Shank3
MW: 184 kD
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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