Anti-SH2D1A (SH2 Domain Protein 1A, Duncan Disease SH2-protein, DSHP, EBVS, FLJ18687, FLJ92177, HGNC

Anti-SH2D1A (SH2 Domain Protein 1A, Duncan Disease SH2-protein, DSHP, EBVS, FLJ18687, FLJ92177, HGNC
Item number Size Datasheet Manual SDS Delivery time Quantity Price
S1013-31E3.100 100 µg - -

3 - 19 business days*

675.00€
 
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B... more
Product information "Anti-SH2D1A (SH2 Domain Protein 1A, Duncan Disease SH2-protein, DSHP, EBVS, FLJ18687, FLJ92177, HGNC"
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. Applications: Suitable for use in ELISA and Western Blot. Other applications have not been tested. , Recommended Dilutions: Peptide ELISA Titer: 1:16,000, Western Blot: 0.3-1ug/ml ~16kD band observed in Human Thymus lysates (calculated MW of 14.2xkD according to NP_002342.1). In transfected HEK293 transiently expressing SH2D1A a band of approx. 16kD is observed. This band is not observed in the non-transfected HEK293., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-SLAM-associated protein, Anti-Duncan disease SH2-protein, Anti-SH2 domain-containing protein 1A, Anti-T-cell signal transduction molecule SAP, Anti-Signaling lymphocytic activation molecule-associated protein
Supplier: United States Biological
Supplier-Nr: S1013-31E3

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Goat
Species reactivity: human
Immunogen: Synthetic peptide corresponding to C-HKRYFRKIKN, from the internal region of human SH2D1A (NP_002342.1, NP_001108409.1).
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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