Anti-SH2D1A

Polyclonal Antibody against Human SH2D1A, Gene description: SH2 domain containing 1A, Alternative Gene Names: DSHP, EBVS, IMD5, LYP, MTCP1, SAP, XLP, XLPD, Validated applications: ICC, Uniprot ID: O60880, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C. Protein function: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3. [The UniProt Consortium] Mouse gene identity: 96% Rat gene identity: 96%