Anti-SGT1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A302-776A-T	10 µl (2 µg)		-		2 - 8 business days*		165.00€
A302-776A	100 µl		-		2 - 8 business days*		586.00€

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Protein function: Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated... more

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Product information "Anti-SGT1"

Protein function: Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212). [The UniProt Consortium]

Keywords:	Anti-ECD, Anti-hSGT1, Anti-Human suppressor of GCR two, Anti-Protein ecdysoneless homolog
Supplier:	Bethyl Laboratories
Supplier-Nr:	A302-776A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: orangutan, rhesus monkey, gorilla, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by A302-776A-T maps to a region between residue 614 and 644 of human Suppressor of GCR2 using the numbering given in entry NP_009196.1 (GeneID 11319).
Format:	Antigen Affinity Purified