Anti-SFRS3

Anti-SFRS3
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-R32173 100 µg - -

3 - 10 business days

503.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Splicing factor, arginine/serine-rich 3,... more
Product information "Anti-SFRS3"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Splicing factor, arginine/serine-rich 3, also known as SRSF3, is a protein that in humans is encoded by the SFRS3 gene. The protein encoded by this gene is a member of the serine/ arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. Protein function: Splicing factor that specifically promotes exon- inclusion during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). Also functions as export adapter involved in mRNA nuclear export such as of histone H2A (PubMed:11336712, PubMed:18364396). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway), enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). RNA-binding is semi-sequence specific (PubMed:17036044). [The UniProt Consortium]
Keywords: Anti-SFRS3, Anti-SRSF3, Anti-Pre-mRNA-splicing factor SRP20, Anti-Serine/arginine-rich splicing factor 3, Anti-Splicing factor, arginine/serine-rich 3, SFRS3 Antibody
Supplier-Nr: R32173

Properties

Application: WB
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Amino acids MHRDSCPLDCKVYVGNLGNNGNKTELERA of human SFRS3 were used as the immunogen for the SFRS3 antibody.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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