Anti-SFMBT2 / Scm-like with four MBT domains protein 2

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. SFMBT2 antibody detects Scm-like with four MBT domains protein 2, a chromatin-associated transcriptional repressor involved in epigenetic gene silencing. The UniProt recommended name is Scm-like with four MBT domains protein 2 (SFMBT2). This protein belongs to the polycomb group (PcG)-related MBT family, which regulates gene expression through chromatin compaction and histone modification recognition.Functionally, SFMBT2 antibody identifies a 1220-amino-acid nuclear protein that binds to methylated histones, particularly histone H3 dimethylated on lysine 9 (H3K9me2) and lysine 27 (H3K27me2). SFMBT2 functions as a transcriptional corepressor by stabilizing repressive chromatin domains, thereby restricting transcriptional activation of developmental and cell cycle genes. It is a structural homolog of Drosophila Scm (Sex comb on midleg), which participates in Polycomb repressive complex formation.The SFMBT2 gene is located on chromosome 8q13.3 and encodes a protein widely expressed in embryonic and adult tissues, with enrichment in stem cells and reproductive organs. SFMBT2 plays a key role in early embryogenesis and trophoblast differentiation by maintaining chromatin architecture and silencing specific developmental genes. In trophoblast stem cells, SFMBT2 contributes to maintenance of stemness and regulation of imprinted gene expression.Epigenetically, SFMBT2 interacts with histone deacetylases (HDACs) and other repressive complexes to enforce gene silencing. It binds methylated histones through its MBT (malignant brain tumor) domains, which function as methyl-lysine recognition modules. Loss or depletion of SFMBT2 leads to de-repression of silenced loci, chromatin decondensation, and transcriptional misregulation. In cancer, altered SFMBT2 expression has been observed in hepatocellular carcinoma and prostate cancer, implicating it in tumor growth and chromatin remodeling.SFMBT2 antibody is widely used in epigenetics, chromatin biology, and transcriptional regulation studies. It is suitable for immunoblotting, chromatin immunoprecipitation (ChIP), and immunofluorescence to investigate SFMBT2 localization and histone interactions. This antibody aids in exploring PcG-mediated gene repression and chromatin dynamics in development and disease. It also helps characterize the role of SFMBT2 in maintaining heterochromatin and transcriptional stability.Structurally, SFMBT2 contains four MBT domains arranged in tandem that form a histone-binding scaffold, along with N-terminal coiled-coil motifs that mediate protein-protein interactions. Post-translational regulation includes phosphorylation and ubiquitination, which may influence chromatin association. NSJ Bioreagents provides SFMBT2 antibody reagents validated for use in chromatin modification, epigenetic regulation, and developmental biology research.