Anti-SEZ6L2 / Seizure 6-like protein 2

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. SEZ6L2 antibody detects Seizure 6-like protein 2, a type I transmembrane glycoprotein implicated in synaptic development, neural signaling, and brain homeostasis. SEZ6L2 belongs to the seizure-related gene family and is involved in regulating excitatory synapse formation and neuronal communication. The SEZ6L2 antibody is widely used in neuroscience, neurodevelopmental, and psychiatric disorder research to study synapse regulation and neuronal signaling pathways.SEZ6L2 is encoded by the SEZ6L2 gene located on human chromosome 16p11.2. The protein is approximately 922 amino acids long and contains three CUB domains and several complement control protein (CCP) repeats, which facilitate protein interactions in the extracellular environment. SEZ6L2 localizes to the neuronal plasma membrane and is enriched in dendritic and axonal compartments.The SEZ6L2 antibody detects a 100 kilodalton band by western blot and reveals punctate synaptic staining in neuronal cultures. SEZ6L2 participates in the regulation of synaptic vesicle cycling, neuronal excitability, and calcium-dependent signaling. It also modulates the maturation of AMPA receptors, influencing excitatory synaptic transmission and plasticity. In the central nervous system, SEZ6L2 contributes to circuit development and synaptic pruning.Mutations or deletions of SEZ6L2 have been linked to autism spectrum disorder, intellectual disability, and schizophrenia, reflecting its critical role in neural connectivity. Dysregulation of SEZ6L2 expression affects neuronal survival and synaptic balance, contributing to altered neurotransmission and cognitive dysfunction. It is also expressed in certain cancers, where it may promote cell adhesion and metastasis.As a neuronal surface protein involved in communication and network formation, SEZ6L2 serves as a valuable target for studying synaptic biology and neurological disease mechanisms. NSJ Bioreagents provides a validated SEZ6L2 antibody optimized for its applications, supporting research into neuronal connectivity, synaptic regulation, and neurodevelopmental disorders.