Anti-Set2

Make to order. Production time: 70-80 business days. Deliverables: 1. 200 µg antigen (used as positive control), 2. 1 ml pre-immune serum (used as negative control) , 3. Rabbit polyclonal antibody, antigen affinity purified. Quality Guarantee: 1. Antibody purity > 90% confirmed by SDS-PAGE, 2. Antibody titer > 1: 64,000 confirmed by ELISA, 3. WB positive with the immunogen protein (not applicable for synthetic peptide). Applications: ELISA, WB (positive for the recombinant immunogen protein/peptide). Buffer: Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, pH 7.4. Protein function: Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) (PubMed:17560546, PubMed:17936709). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (PubMed:17560546). Involved in dosage compensation in males (X chromosome dosage compensation) by mediating formation of H3K36me3, a mark recognized by msl-3 component of the MSL complex (PubMed:17936709). In addition to its role in dosage compensation in males, promotes germline stem cell differentiation in females: catalyzes formation of H3K36me3, promoting recruitment of msl- 3 and subsequent recruitment of the ATAC complex, leading to transcription of genes, such as RpS19b (PubMed:34878097). [The UniProt Consortium]