Anti-SET

Anti-SET
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-262A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-262A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-262A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: Multitasking protein, involved in apoptosis, transcription, nucleosome assembly... more
Product information "Anti-SET"
Protein function: Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T- lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins, however, isoform 2 specific activity is higher. [The UniProt Consortium]
Keywords: Anti-SET, Anti-TAF-I, Anti-IGAAD, Anti-PHAPII, Anti-I-2PP2A, Anti-Protein SET, Anti-HLA-DR-associated protein II, Anti-Template-activating factor I, Anti-Phosphatase 2A inhibitor I2PP2A, Anti-Inhibitor of granzyme A-activated DNase
Supplier: Bethyl Laboratories
Supplier-Nr: A302-262A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Mouse, Rat)
Immunogen: synthetic peptide. The epitope recognized by A302-262A-T maps to a region between residue 175 and 225 of human SET nuclear oncogene using the numbering given in entry NP_001116293.1 (GeneID 6418).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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