Anti-SEPTIN8 / Septin 8, clone 30S14

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. SEPTIN8 antibody detects Septin 8, encoded by the SEPTIN8 gene. Septin 8 is a member of the septin family of GTP binding cytoskeletal proteins involved in cytokinesis, vesicle trafficking, and cellular morphogenesis. SEPTIN8 antibody provides researchers with a specific reagent to study cytoskeletal organization, cell division, and neuronal development.Septins form hetero oligomeric complexes that polymerize into filaments and higher order structures. Research using SEPTIN8 antibody has shown that Septin 8 contributes to filament assembly, acting as a structural scaffold at the plasma membrane and division sites. Septin complexes coordinate with actin and microtubules to regulate cell polarity and compartmentalization, ensuring proper cell division and morphogenesis.In neurons, Septin 8 plays roles in dendritic branching and synapse formation. Studies with SEPTIN8 antibody have demonstrated that it localizes to dendritic spines and regulates cytoskeletal rearrangements required for synaptic plasticity. Dysregulation of Septin 8 expression or function may impair neural connectivity and contribute to neurological disorders.Septin dysregulation has been linked to cancer and neurodegeneration. Research using SEPTIN8 antibody has revealed that abnormal expression influences cell cycle progression, apoptosis, and tumor growth. In the nervous system, altered Septin 8 activity has been associated with psychiatric and developmental disorders, reflecting its importance in synaptic regulation and cytoskeletal dynamics.SEPTIN8 antibody is applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting identifies endogenous protein levels, immunohistochemistry highlights expression in proliferative tissues, and immunofluorescence demonstrates cytoskeletal localization. These applications make SEPTIN8 antibody a versatile reagent in cytoskeletal and neuronal research.By supplying validated SEPTIN8 antibody reagents, NSJ Bioreagents supports studies into cytoskeletal organization, neuronal development, and disease biology. Detection of Septin 8 provides insight into how septin family proteins regulate essential cellular processes.