Anti-SELL / L-Selectin / LAM-1

In 1X PBS, pH 7.4, with 0.09% sodium azide. L-Selectin, also known as CD62L, SELL and LAM-1, is a cell adhesion molecule found on the surface of leukocytes, or white blood cells. It plays a role in the immune response by facilitating the binding of leukocytes to endothelial cells in the blood vessels, allowing them to migrate to sites of infection or inflammation. One of the key functions of L-Selectin is its involvement in the process of leukocyte rolling. When an infection or injury occurs, inflammatory signals are released that trigger the expression of adhesion molecules on the surface of endothelial cells. L-Selectin on leukocytes then binds to its ligands on the endothelial cells, causing the leukocytes to roll along the vessel wall. This rolling motion slows down the leukocytes and allows them to survey the endothelial surface for signs of infection. Once the leukocytes have identified the site of infection, they can firmly adhere to the endothelial cells and extravasate, or migrate, into the surrounding tissue. L-Selectin plays a critical role in this step by mediating the initial interaction between leukocytes and endothelial cells. Without L-Selectin, leukocytes would not be able to efficiently migrate to the site of infection, impairing the immune response. In addition to its role in leukocyte trafficking, L-Selectin also plays a role in regulating the activation and function of leukocytes. Studies have shown that L-Selectin signaling can modulate the production of cytokines and chemokines, which are key mediators of inflammation. By influencing the inflammatory response, L-Selectin can help regulate the magnitude and duration of immune reactions, preventing excessive tissue damage. Furthermore, L-Selectin has been implicated in a variety of inflammatory and autoimmune diseases. Dysregulation of L-Selectin expression or function can lead to abnormal leukocyte trafficking and contribute to chronic inflammation. Understanding the role of L-Selectin in these conditions may provide insights into potential therapeutic targets for treating inflammatory diseases. Protein function: Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28011641, PubMed:28489325). Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641). [The UniProt Consortium]