Anti-SEC61B / Sec61 subunit beta

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. The SEC61B antibody targets Protein transport protein Sec61 subunit beta, a component of the Sec61 translocon complex encoded by the SEC61B gene. The Sec61 complex mediates the translocation of nascent polypeptides across and into the endoplasmic reticulum (ER) membrane, an essential step in the biosynthesis of secretory and membrane proteins. The SEC61B antibody enables precise detection of this translocon subunit and supports studies of protein targeting, membrane insertion, and ER homeostasis.Protein transport protein Sec61 subunit beta forms part of the heterotrimeric Sec61 channel, together with the alpha (SEC61A) and gamma (SEC61G) subunits. While the alpha subunit forms the central pore that guides polypeptides through the membrane, the beta subunit participates in channel assembly, stability, and interaction with ribosomes and chaperones. The SEC61B antibody provides a reliable means of detecting this small yet essential component of the translocon, helping researchers understand how it contributes to co-translational protein translocation and membrane integration.In addition to its structural role, Protein transport protein Sec61 subunit beta is involved in post-translational translocation of proteins and quality control mechanisms that prevent accumulation of misfolded peptides. The SEC61B antibody can be used to monitor ER function under stress conditions, including the unfolded protein response and ER-associated degradation (ERAD). By visualizing SEC61B distribution and expression levels, investigators gain insights into how protein import efficiency correlates with ER capacity and cell health.The Sec61 complex also functions as a retrotranslocation channel, allowing misfolded proteins to exit the ER for cytosolic degradation by the proteasome. This dual functionality links SEC61B to cellular proteostasis and stress adaptation. The SEC61B antibody is instrumental in exploring these mechanisms and clarifying how perturbations in Sec61 function contribute to diseases such as cystic fibrosis, diabetes, and neurodegeneration. Its detection of Protein transport protein Sec61 subunit beta expression enables both basic and translational research on ER transport regulation.The SEC61B antibody is suitable for western blotting, immunofluorescence, and immunohistochemistry. It produces distinct ER localization patterns consistent with translocon distribution. NSJ Bioreagents supplies this antibody as a rigorously tested reagent designed for reproducibility across experimental systems. By providing dependable detection of Protein transport protein Sec61 subunit beta, the SEC61B antibody supports molecular research into secretory pathway dynamics, protein biogenesis, and ER function in normal and disease states.