Anti-SCN1B / Sodium channel subunit beta-1

In 1X PBS, pH 7.4, with 0.09% sodium azide. Sodium channel subunit beta-1 (SCN1B) is a protein that is essential for the proper functioning of sodium channels in our cells. Sodium channels are responsible for the movement of sodium ions across cell membranes, playing a vital role in regulating cell excitability and communication. SCN1B is one of several subunits that work together to form functional sodium channels, with each subunit contributing to the overall activity and properties of the channel. One of the key roles of SCN1B is to modulate the activity of sodium channels, influencing their opening and closing dynamics. This modulation is crucial for controlling the flow of sodium ions into cells, which is essential for proper nerve signaling and muscle function. In addition to its role in regulating sodium channel activity, SCN1B also helps to stabilize the structure of sodium channels and promote their trafficking to the cell membrane. Research has shown that mutations in the SCN1B gene can lead to disruptions in sodium channel function, resulting in a variety of neurological and cardiovascular disorders. For example, mutations in SCN1B have been linked to epilepsy, as well as arrhythmias and heart failure. Protein function: Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:14622265, PubMed:15525788, PubMed:18464934, PubMed:19710327, PubMed:29992740, PubMed:36696443, PubMed:8125980, PubMed:8394762). The accessory beta subunits participate in localization and functional modulation of the Nav channels (PubMed:15525788, PubMed:19710327, PubMed:29992740). Modulates the activity of SCN1A/Nav1.1, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN4A/Nav1.4, SCN5A/Nav1.5, SCN8A/Nav1.6, SCN9A/Nav1.7 and SCN10A/Nav1.8 (PubMed:14622265, PubMed:15525788, PubMed:18464934, PubMed:30765606, PubMed:36696443, PubMed:8125980, PubMed:8394762). [The UniProt Consortium]