Anti-SCML2 / Sex comb on midleg-like protein 2

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. SCML2 antibody detects Sex comb on midleg-like protein 2, a Polycomb group protein involved in chromatin silencing and transcriptional repression. The UniProt recommended name is Sex comb on midleg-like protein 2 (SCML2). This epigenetic regulator participates in the formation of Polycomb repressive complexes that maintain gene silencing during development and differentiation.Functionally, SCML2 antibody identifies a 715-amino-acid nuclear protein containing SAM and MBT domains that mediate protein-protein and chromatin interactions. SCML2 binds histone tails modified by methylation, such as H3K9me and H4K20me, to recruit other Polycomb factors and repress transcription. It is particularly enriched in testis, suggesting specialized functions in germ cell chromatin organization.The SCML2 gene is located on the X chromosome (Xp22.12) and is expressed in germ cells, embryonic tissues, and certain somatic cells. SCML2 coordinates chromatin compaction and transcriptional silencing by recognizing repressive histone marks and interacting with PRC1 components. It contributes to maintaining stem cell identity and regulating spermatogenesis.Pathologically, altered SCML2 expression has been linked to developmental defects, infertility, and cancer. Dysregulation may disrupt Polycomb-mediated silencing, leading to aberrant gene expression and loss of epigenetic stability. Research using SCML2 antibody aids in studying chromatin biology, gene silencing, and germline development.SCML2 antibody is validated for western blotting, chromatin immunoprecipitation, and immunofluorescence to detect Polycomb group proteins. NSJ Bioreagents provides SCML2 antibody reagents optimized for studies in epigenetics, germ cell biology, and transcriptional regulation.Structurally, Sex comb on midleg-like protein 2 contains a sterile alpha motif (SAM) domain for protein dimerization and two MBT repeats that bind methylated histones. This antibody enables research into SCML2's role in epigenetic repression and chromatin organization.