Anti-scc-2

Make to order. Production time: 70-80 business days. Deliverables: 1. 200 µg antigen (used as positive control), 2. 1 ml pre-immune serum (used as negative control) , 3. Rabbit polyclonal antibody, antigen affinity purified. Quality Guarantee: 1. Antibody purity > 90% confirmed by SDS-PAGE, 2. Antibody titer > 1: 64,000 confirmed by ELISA, 3. WB positive with the immunogen protein (not applicable for synthetic peptide). Applications: ELISA, WB (positive for the recombinant immunogen protein/peptide). Buffer: Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, pH 7.4. Protein function: Plays an important role in the loading of the cohesin complex on to meiotic chromosomes (PubMed:21856158). Forms a heterodimeric complex (also known as cohesin loading complex) with mau-2/SCC4 which mediates the loading of the cohesin complex onto chromatin. Plays an essential role in cell division during embryonic development (PubMed:15146185, PubMed:16802858). Promotes normal chromosome organization during meiosis (PubMed:21856158). Required for the assembly of the synaptonemal complex between homologous chromosomes to promote sister chromatid cohesion during meiosis (PubMed:21856158). Required for chromosome segregation during mitosis and meiosis (PubMed:16802858). Plays a role in DNA double-strand break (DSB) repair during meiotic recombination and promotes the assembly of the 9-1-1 cell-cycle checkpoint response complex which is required for inducing apoptosis in response to DNA damage, at DNA damage sites (PubMed:21856158). [The UniProt Consortium]