Anti-Scavenger Receptor B2/CD36 IgG

CD36, also known as scavenger receptor B2 (SR-B2) or fatty acid translocase (FAT), is a transmembrane glycoprotein that has roles in fatty acid uptake and lipid metabolism and signaling. It is composed of N- and C-terminal cytoplasmic tails, two transmembrane domains, and an extracellular loop that binds to a variety of lipid ligands, including long-chain fatty acids, oxidized LDL, and oxidized phospholipids, and protein ligands, such as thrombospondin (TSP-1), and is subject to post-translational modifications. CD36 is expressed by a variety of cells, including hematopoietic cells such as platelets, monocytes, and macrophages, as well as adipocytes, enterocytes, cardiac and skeletal myocytes, and endothelial and epithelial cells. It also exists as a soluble form, sCD36, which is produced via plasma proteases. CD36 expression is regulated by several transcription factors, including peroxisome proliferator-activated receptor (PPAR), STAT3, and hypoxia-inducible factor-1alpha (HIF-1alpha), in a tissue-dependent manner. It is localized to the plasma membrane and within endosomes, the endoplasmic reticulum, and mitochondria, and is translocated between these compartments in response to various stimuli, including insulin-induced PI3K signaling and muscle contraction-induced AMPK signaling, to regulate fatty acid uptake. It has additional roles in the phagocytosis of apoptotic cells and P. falciparum-infected red blood cells (RBCs), angiogenesis, thrombosis, inflammation, and atherosclerosis, as well as cancer metastasis. Cayman's Scavenger Receptor B2/CD36 IgG Recombinant Monoclonal Antibody can be used for flow cytometry.Synonyms: Fatty Acid Translocase, GPIIIb, GPIV, PAS IV, Platelet Glycoprotein IV, Platelet Glycoprotein 4. Immunogen: This antibody, which contains a mouse IgG1 isoform, was produced as a recombinant protein expressed in HEK293 cells using an engineered construct based on a monoclonal SR-B2/CD36 antibody. Formulation: (Request formulation change), 100 µg of protein G-purified monoclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: HEK293 cells. Isotype: IgG1. Applications: FC. Cross Reactivity: (+) CD36. UniProt Accession #: Q08857.