Anti-SCAP

Anti-SCAP
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-554A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A303-554A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A303-554A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Escort protein required for cholesterol as well as lipid homeostasis. Regulates... more
Product information "Anti-SCAP"
Protein function: Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. [The UniProt Consortium]
Keywords: Anti-SCAP, Anti-PSEC0227, Anti-SREBP cleavage-activating protein, Anti-Sterol regulatory element-binding protein cleavage-activating protein
Supplier: Bethyl Laboratories
Supplier-Nr: A303-554A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan, Rhesus Monkey, Chimpanzee, White-tufted-ear Marmoset, Crab-eating Macaque, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A303-554A-T maps to a region between residue 450 and 500 of human Sterol Regulatory Element Binding Protein Ceavage-Activating Protein using the numbering given in entry NP_036367.2 (GeneID 22937).
Format: Antigen Affinity Purified

Database Information

UniProt ID : Q12770 | Find alternatives
Gene ID GeneID 22937 | Find alternatives

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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