Anti-SATB2

The SATB2 (Special AT-rich Sequence-Binding Protein 2) gene has been identified as part of a chromosomal translocation involving 2q32-q33 that results in isolated cleft palate (CPO). SATB2 is an AT-rich DNA binding protein. In the rat, SATB2 expression is specific to the developing neocortex, and it is suggested to play a role in chromatin organization and gene expression in the brain. Protein function: Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double- stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. [The UniProt Consortium]