Anti-SART3/TIP110 (IHC)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00294-T 10 µl (5+ slides) -

3 - 9 business days

125.00€
IHC-00294 100 µl (50+ slides) -

3 - 9 business days

470.00€
 
Protein function: U6 snRNP-binding protein that functions as a recycling factor of the splicing... more
Product information "Anti-SART3/TIP110 (IHC)"
Protein function: U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC. [The UniProt Consortium]
Keywords: Anti-Tip110, Anti-SART-3, Anti-p110 nuclear RNA-binding protein, Anti-Tat-interacting protein of 110 kDa, Anti-Squamous cell carcinoma antigen recognized by T-cells 3
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00294-T

Properties

Application: IHC, IHC-IF
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan, Chimpanzee, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by IHC-00294 maps to a region between residue 600 and 650 of human squamous cell carcinoma antigen recognized by T-cells 3 (Tat-interacting protein of 110 kDa) using the numbering given in entry NP_055521.1 (GeneID 9733).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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