Anti-SARS-CoV-2 Nucleocapsid Rabbit (Clone RM

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid protein is a viral protein encoded by the N gene in SARS-CoV-2 RNA. SARS-CoV-2 is a member of the Betacoronavirus genus of viruses and has 88% sequence identity with two bat-derived SARS-like CoVs. SARS-CoV-2 nucleocapsid protein is composed of an N-terminal domain (NTD) that binds RNA, a disordered linker region that contains regulatory phosphorylation sites, a C-terminal domain (CTD) that mediates dimerization, and a C-terminal tail. In a similar virus, SARS-CoV, the nucleocapsid protein packages the viral RNA into a helical ribonucleoprotein (RNP) complex that is a template for viral replication. The SARS-CoV nucleocapsid protein is integral for viral self-assembly and is involved in cell cycle regulation. The SARS-CoV-2 nucleocapsid protein gene sequence is greater than 90% similar to the SARS-CoV nucleocapsid protein, and it contains 27 T cell epitopes that are identical to SARS-CoV T cell epitopes. SARS-CoV-2 nucleocapsid protein inhibits the formation of stress granules, which sequester viral factors and are involved in the host antiviral response. SARS-CoV-2 is the causative agent of COVID-19, a primarily respiratory illness characterized by fever, cough, and shortness of breath that can lead to life-threatening complications. Cayman's SARS-CoV-2 Nucleocapsid Rabbit Monoclonal Antibody (Clone RM420) can be used as a capture antibody paired with the detection antibody SARS-CoV-2 Nucleocapsid Chimeric Human Monoclonal Antibody (Clone RMH03) (Cay-42860) in sandwich ELISAs.. Cross reactivity: (+) SARS-CoV-2 nucleocapsid protein: (-) Other common coronaviruses. (+) SARS-CoV-2: .. Protein function: Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. May modulate transforming growth factor-beta signaling by binding host smad3. [The UniProt Consortium]