Anti-S26A8

This gene encodes a member of the SLC26 gene family of anion transporters. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. The expression of this gene appears to be restricted to spermatocytes. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2010], Protein function: Antiporter that mediates the exchange of sulfate and oxalate against chloride ions across a membrane (PubMed:11834742, PubMed:11278976). Stimulates anion transport activity of CFTR (PubMed:22121115, PubMed:23582645). May cooperate with CFTR in the regulation of chloride and bicarbonate ions fluxes required for activation of the ADCY10/PKA pathway during sperm motility and sperm capacitation. May play a role in sperm tail differentiation and motility and hence male fertility. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000. Cellular localization: Membrane , Multi-pass membrane protein . Located at the annulus ring structure within the sperm cell. .