Anti-S1P4

EDG-6 is a member of the endothelial differentiation gene (EDG) G protein-coupled receptor family and is a receptor for sphingosine 1-phosphate (S1P). Binding of S1P to EDG-6 activates Erk, leading to the activation of the transcription factor Elk1 and thus the mitogen-activated protein kinase (MAPK) signal transduction pathway. The protein is specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Human EDG-6 gene is intronless and is mapped to chromosome 19p13.3 at the D19S120 marker.Synonyms: EDG-6, S1PR4, Sphingosine-1-phosphate Receptor 4. Immunogen: synthetic peptide from human S1P4 within the region of amino acids 1-50. Formulation: (Request formulation change), 100 µg of peptide affinity-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.. Host: Rabbit. Applications: ICC, IF, WB. Origin: Animal/Rabbit.