Anti-S100P / S100 calcium binding protein P, clone MSVA-480R

Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide. S100 calcium binding protein P (S100P) is a member of the S100 family of EF-hand calcium-binding proteins encoded by the S100P gene and expressed in a variety of epithelial tissues. S100P Antibody for IHC enables visualization of S100 Calcium Binding Protein P expression in formalin-fixed paraffin-embedded tissue sections using immunohistochemistry. S100P participates in calcium-dependent signaling pathways that regulate cellular proliferation, migration, and survival, and it has been studied extensively in epithelial biology and tumor-associated signaling processes.Immunohistochemistry studies commonly demonstrate cytoplasmic and occasionally nuclear S100P staining within epithelial cell populations. In histological tissue sections, S100P expression is frequently observed in glandular epithelial cells and in epithelial-derived tumors, allowing investigators to visualize S100P-positive epithelial cells within intact tissue architecture. These staining patterns enable evaluation of cellular localization and comparison of S100P expression across different tissues using immunohistochemistry-based analysis.Large-scale expression profiling using human tissue microarray (TMA) panels provides an efficient approach for evaluating S100P distribution across many tissue types simultaneously. In human tissue microarray panels containing multiple normal and cancer tissues, S100P staining is commonly observed in epithelial compartments while surrounding stromal tissues often remain negative. Such TMA-based immunohistochemistry analysis allows investigators to examine patterns of S100P expression across numerous tissues under standardized staining conditions while preserving histological context.S100P has also attracted considerable attention in pathology research because S100P-positive pancreatic ductal adenocarcinoma cells are frequently observed in tumor tissue sections. This pathology-associated expression pattern has led to the use of S100P immunohistochemistry as a marker studied in pancreatic cancer biology and epithelial tumor progression. Detection of S100P expression in tissue sections therefore provides insight into epithelial cell differentiation and tumor-associated signaling pathways.A recombinant rabbit monoclonal antibody, clone MSVA-480R, recognizes S100P protein and supports immunohistochemical detection of S100 Calcium Binding Protein P in human tissues. When applied to FFPE tissue sections and human tissue microarray (TMA) panels containing multiple normal and cancer tissues, S100P Antibody for IHC highlights epithelial cell populations expressing S100P. These staining patterns allow researchers to evaluate tissue-specific expression, examine epithelial cell distribution, and study the role of S100P in epithelial biology and tumor-associated signaling pathways.This antibody is also part of a broader collection of IHC antibodies validated by tissue microarray analysis, supporting consistent staining across normal and cancer tissues.