Anti-S100A7 (Protein S100-A7, Psoriasin, S100 Calcium-binding Protein A7, PSOR1, S100A7C)

S100A7 is an 11-13kD member of the S101 family, EF-hand superfamily of Ca-binding proteins. It is produced by keratinocytes and exists as both an intracellular and extracellular polypeptide. Intercellularly, it binds to E/FABP and may participate in fatty acid metabolism. Extracellularly, it is both monomeric and heterooligomeric and exhibits antibacterial properties. Human S100A7 is 101aa in length. It contains two EF-hand motifs aa13-48, 50-85, three zinc-binding His residues, one high-affinity Ca-binding site aa63-74 and an overlapping antibacterial sequence aa35-80. There appear to be no meaningful rodent structural orthologs. Human S100A7 is 93aa identical to human S100A15/7A, and the S100A7 gene has a duplication (S100A7B) that is 54aa identical to S100A7. Applications: Suitable for use in immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: 8-25ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.